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Clonal architecture and single-cell transcriptome landscape in Richter's syndrome

Heng Li1,2,3, Lingli Yuan1,2,3, Peilong Wang1,2

  • 1Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

British Journal of Haematology
|July 4, 2023
PubMed
Summary

No abstract available in PubMed .

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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