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Drug extravasation with Enfortumab vedotin
Christopher Ryan Grant1, Dimitri de Kouchkovsky2, Arash Rezazadeh Kalebasty3
1Department of Medicine, University of California Irvine Medical Center, Orange, CA, USA.
Summary
Enfortumab vedotin extravasation can cause skin reactions like blisters and cellulitis. Prompt, conservative management allows patients to safely resume treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Enfortumab vedotin (EV) is an antibody-drug conjugate used for urothelial carcinoma.
- It carries a rare risk of extravasation and soft tissue reactions.
Observation:
- Two cases of EV extravasation leading to bullae and cellulitis are presented.
- These reactions occurred after intravenous administration of enfortumab vedotin.
Findings:
- Conservative management, including treatment for cellulitis without surgery, was effective.
- Patients were able to restart enfortumab vedotin therapy without further complications.
Implications:
- Enfortumab vedotin may act as a vesicant upon extravasation.
- Preventive measures and specific management strategies (aspiration, catheter removal, compresses, documentation) are recommended for extravasation events.
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