Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

12.1K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
12.1K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
Cancer02:18

Cancer

48.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.8K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Metastasis02:30

Metastasis

5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Fixed-Duration Ven-I Regimen in CLL: Expert Insight and AI Comparison.

Hematological oncology·2026
Same author

SGLT2i Dapagliflozin in primary prevention of chemotherapy induced cardiotoxicity in breast cancer patients treated with neo-adjuvant anthracycline-based chemotherapy +/- trastuzumab: rationale and design of the multicenter PROTECT trial.

Cardio-oncology (London, England)·2025
Same author

Management of the ulnar nerve using an adipofascial flap in elbow surgery.

Musculoskeletal surgery·2025
Same author

Anterior segment ischemia and ischemic optic neuropathy following encircling scleral buckling surgery and air tamponade.

American journal of ophthalmology case reports·2025
Same author

Squamous cell carcinoma in rare case of Huriez Syndrome: The role of distant flaps.

JPRAS open·2025
Same author

Selective anti-CXCR2 receptor blockade by AZD5069 inhibits CXCL8-mediated pro-tumorigenic activity in human thyroid cancer cells in vitro.

Journal of endocrinological investigation·2024
Same journal

Retraction Note: Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study.

European review for medical and pharmacological sciences·2026
Same journal

Retraction Note: A multicenter clinical study with myo-inositol and alpha-lactalbumin in Mexican and Italian PCOS patients.

European review for medical and pharmacological sciences·2026
Same journal

Retraction Note: Oxycodone inhibits myocardial cell apoptosis after myocardial ischemia-reperfusion injury in rats via RhoA/ROCK1 signaling pathway.

European review for medical and pharmacological sciences·2026
Same journal

Intracoronary stem cell transplant in ischemic heart disease: a meta-analysis of randomized trials.

European review for medical and pharmacological sciences·2026
Same journal

From models to medicine: advanced preclinical systems and AI enabling RNA therapeutics in triple-negative breast cancer.

European review for medical and pharmacological sciences·2026
Same journal

Association of serum asprosin levels with obesity indices and metabolic parameters in adults.

European review for medical and pharmacological sciences·2026
See all related articles

Related Experiment Video

Updated: Jul 24, 2025

Pancreatic Tissue Dissection to Isolate Viable Single Cells
08:04

Pancreatic Tissue Dissection to Isolate Viable Single Cells

Published on: May 26, 2023

2.8K

Cancer progression: a single cell perspective.

L Ermini1, S Taurone, A Greco

  • 1Department of Cancer Research, NORLUX Neuro-Oncology Laboratory, Luxembourg Institute of Health L-1526, Luxembourg, Luxembourg. luca.ermini@yahoo.co.uk.

European Review for Medical and Pharmacological Sciences
|July 4, 2023
PubMed
Summary
This summary is machine-generated.

Cancer progression involves evolutionary dynamics driven by single-cell changes and microenvironment interactions. Advanced single-cell multi-omics studies reveal genetic and non-genetic factors for precision cancer medicine.

More Related Videos

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

12.5K
Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties
08:19

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Published on: May 19, 2023

1.7K

Related Experiment Videos

Last Updated: Jul 24, 2025

Pancreatic Tissue Dissection to Isolate Viable Single Cells
08:04

Pancreatic Tissue Dissection to Isolate Viable Single Cells

Published on: May 26, 2023

2.8K
Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

12.5K
Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties
08:19

Author Spotlight: Shear Assay Protocol for the Determination of Single-Cell Material Properties

Published on: May 19, 2023

1.7K

Area of Science:

  • Oncology
  • Evolutionary Biology
  • Genomics

Background:

  • Tumor tissues comprise diverse malignant and non-malignant cells, forming a complex ecosystem that influences cancer biology and treatment response.
  • Cancer cells evolve genotypic and phenotypic changes to enhance fitness and overcome treatment resistance.
  • Tumorigenesis is an evolutionary process driven by single-cell changes interacting with the local microenvironment.

Approach:

  • This review examines cancer complexity from a single-cell perspective, introducing single-cell omics.
  • It highlights the evolutionary dynamics governing cancer progression and metastasis.
  • The review surveys single-cell technologies, focusing on multi-omics approaches.

Key Points:

  • Single-cell technologies enable detailed analysis of cancer development.
  • Evolutionary dynamics and microenvironment interactions are critical to cancer progression.
  • Multi-omics studies integrate genetic and non-genetic factors in cancer research.

Conclusions:

  • Understanding single-cell evolution and interactions is key to deciphering cancer biology.
  • Single-cell multi-omics approaches promise to advance precision medicine for cancer treatment.