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Candida auris from colonisation to candidemia: A four-year study
Juan Vicente Mulet Bayona1, Nuria Tormo Palop1, Carme Salvador García1
1Department of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, Valencia, Spain.
Mycoses
|July 4, 2023
Summary
Candida auris is a resistant pathogen causing severe infections. Identifying risk factors like APACHE II score and catheter use is crucial for early detection and management of candidemia in colonized patients.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Healthcare Epidemiology
Background:
- Candida auris is a multi-drug resistant pathogen causing healthcare-associated infections.
- Its ability to colonize patients and surfaces facilitates outbreaks in critical care settings.
Purpose of the Study:
- To evaluate a 4-year Candida auris outbreak.
- Identify risk factors for candidemia in colonized patients.
- Analyze therapeutic measures and outcomes for candidemia and colonization.
Main Methods:
- Retrospective case-control study from September 2017 to September 2021.
- Data collected from patients at Consorcio Hospital General Universitario de Valencia, Spain.
- Analysis of risk factors for developing candidemia in previously colonized patients.
Main Results:
- Candida auris affected 550 patients; 210 had positive clinical samples.
- Isolates showed uniform resistance to fluconazole; low resistance to echinocandins and ampicillin B.
- Independent risk factors for candidemia included APACHE II, digestive disease, and catheter presence. Mortality rates were high for both candidemia (32.6%) and colonization (33.7%).
Conclusions:
- Candidemia is a frequent and severe infection caused by Candida auris.
- Identified risk factors aid in detecting high-risk patients.
- Adequate surveillance of Candida auris colonization is essential for effective management.
