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Updated: Jul 24, 2025

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
Published on: April 4, 2025
[Balloon dilation treatment of primary obstructive megaureter in children]
D A Lebedev1, I B Osipov1, M I Komissarov1
1Department of Urology Federal State Budget Educational Institution of Higher Education St. Petersburg State Pediatric Medical University of the Ministry of Health of Russian Federation, Saint-Petersburg, Russia.
Insights
Ureteral stricture balloon dilation effectively treats primary obstructive megaureter in children, with nearly 80% achieving good outcomes. Stricture length over 10 mm and difficult ballooning increase failure risk.
Area of Science:
- Pediatric Urology
- Minimally Invasive Surgery
- Ureteral Stricture Treatment
Context:
- Primary obstructive megaureter is a congenital condition affecting the urinary tract in children.
- Ureteral strictures can impede urine flow, leading to kidney damage.
- Balloon dilation offers a less invasive approach compared to open surgery.
Purpose:
- To evaluate the effectiveness of single balloon dilation for ureteral strictures in children with primary obstructive megaureter.
- To identify predictors of treatment success and failure.
Summary:
- A study of 79 children (92 ureters) with primary obstructive megaureter treated with balloon dilation showed no intraoperative complications.
- Postoperative pyelonephritis occurred in 18.98% of cases.
- Urodynamic normalization was observed in 79.74% of patients, with a follow-up of 1 to 10 years.
Impact:
- Nearly 80% of children with primary obstructive megaureter can be successfully treated with balloon dilation.
- Stricture length exceeding 10 mm and technical difficulties during dilation are associated with a higher risk of treatment failure.
- Postoperative pyelonephritis is a predictor of adverse outcomes.
Purpose:
Investigation of the results of ureteral stricture single balloon dilation in children with primary obstructive megaureter.
Materials And Methods:
Since 2012 to 2020 79 children (65 boys and 15 girls) with primary obstructive megaureter of II and III grades who had 92 affected ureters were operated on by method of ureteral stricture balloon dilation. Duration of postoperative stenting period was Me=68 [48; 91] days, bladder catheterization period - Me=15 [5; 61] days. Follow-up was from 1 to 10 years.
Results:
There were no intraoperative complications in the group of investigation. Pyelonephritis exacerbation in the early postoperative period occurred in 15 cases (18,98%). Control comprehensive examination revealed that urodynamics of 63 children (79,74%) tended to normalization what persisted in the future. There was no positive dynamics in 16 cases (20,25%). Vesico-ureteral reflux was revealed in 4 cases.
Discussion:
Assessment of impact of various predictors (passport, urodynamic, infectious, anatomic, operation and postoperative period characteristics) on the treatment results proved that the effectiveness of the procedure depends on the following factors: ureteral stricture length (M-U Test U=202,5 p=0,0002) and features of the stricture rapture during ballooning (Fisher exact p=0,0006). There was significant difference in results in the group of up to 10 mm inclusive stricture length and the longer stricture group (Fisher exact p=0,00001). High activity of pyelonephritis in postoperative period was the predictor of adverse outcome (Fisher exact p=0,00001).
Conclusion:
Practically 80% of children with primary obstructive megaureter may be reliably cured by the method of ureteral stricture balloon dilation. The risk of intervention failure is greatly increased in case of the stricture length is more than 10 mm and technical difficulties of ballooning indicating a high resistance of the narrowed portion of the ureter to dilation.
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