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Juvenile idiopathic arthritis and its associated uveitis

Arash Maleki1,2,3, Priya D Patel2,3, C Steven Foster2,3,4

  • 1Department of Ophthalmology, University of Florida, Gainesville, FL, USA.

Expert Review of Clinical Immunology
|July 4, 2023
PubMed

Insights

Juvenile idiopathic arthritis (JIA) and its associated uveitis require lifelong monitoring and treatment. New biologic therapies show promise, but more research is needed for better outcomes in children and adults.

Area of Science:

  • Pediatric Rheumatology
  • Ophthalmology

Background:

  • Juvenile idiopathic arthritis (JIA) is a leading chronic rheumatic condition in children.
  • Uveitis is the most frequent extra-articular manifestation of JIA, posing a significant risk to vision.

Purpose of the Study:

  • To review the epidemiology, risk factors, clinical presentation, diagnostics, treatments, and complications of JIA and JIA-associated uveitis.
  • To discuss current and emerging therapeutic strategies, including conventional immunomodulatory therapy and biologic response modifiers.
  • To examine the long-term disease course, functional outcomes, and quality of life for patients with JIA and associated uveitis.

Main Methods:

  • Comprehensive literature review of JIA and JIA-associated uveitis.
  • Analysis of epidemiological data, clinical findings, and treatment outcomes.
  • Evaluation of immunomodulatory and biologic therapies.

Main Results:

  • Biologic agents have improved outcomes for JIA and associated uveitis over the last 30 years.
  • A substantial number of patients necessitate ongoing treatment into adulthood.
  • Limited FDA-approved biologic options exist for JIA-associated uveitis.

Conclusions:

  • Lifelong screening and monitoring are essential for patients with JIA and associated uveitis.
  • Further randomized clinical trials are crucial to explore novel medications for JIA-associated uveitis.
  • Enhanced therapeutic strategies are needed to improve long-term management and quality of life.
Abstract

Keywords:
ArthritisJIAJuvenile idiopathic arthritisbiologic response modifierenthesitisimmunomodulatory therapyoligoarticular, polyarticularuveitis

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