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Updated: Jul 24, 2025
08:19
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
16.1K
Flip a coin: cell senescence at the maternal-fetal interface†
Guang-Shun Gong1, Kahindo P Muyayalo2, Yu-Jing Zhang1
1Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Biology of Reproduction
|July 4, 2023
Summary
Cell senescence plays a vital role in healthy pregnancy but its dysregulation can lead to pregnancy complications. Understanding cell senescence is key to developing new therapies for pregnancy disorders.
Area of Science:
- Reproductive biology
- Cellular senescence
- Maternal-fetal interface
Background:
- Cell senescence is crucial for normal pregnancy, supporting maternal health, placental development, and fetal growth.
- Aberrant cell senescence is linked to pregnancy issues like preeclampsia, fetal growth restriction, and preterm birth.
Approach:
- This review examines the dual role of cell senescence at the maternal-fetal interface.
- It highlights the beneficial "bright side" in decidualization, placentation, and parturition.
- It also explores the detrimental "dark side" of senescence deregulation in pregnancy complications.
Key Points:
- Cell senescence is essential for successful pregnancy outcomes.
- Dysregulated cell senescence contributes to various pregnancy-associated abnormalities.
- Therapeutic strategies targeting cell senescence are emerging.
Conclusions:
- Further comprehension of cell senescence's role in pregnancy is necessary.
- Modulating cell senescence offers potential for novel therapeutic interventions in pregnancy disorders.
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