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Updated: Jul 24, 2025
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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
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Hepatitis mortality in Brazil and regions, 2001-2020: temporal trend and spatial analysis
Laryssa Fialho de Oliveira Sousa1, Evelen Rouse de Souza Santos1, Rayssa Mendonça Oliveira1
1Universidade Tiradentes - Aracaju (SE), Brazil.
Summary
Hepatitis A, B, and unspecified viral hepatitis mortality decreased in Brazil between 2001-2020. However, chronic viral hepatitis deaths rose in the North and Northeast regions, indicating a concerning spatial trend.
Area of Science:
- Public Health
- Epidemiology
- Infectious Diseases
Background:
- Hepatitis remains a significant public health concern globally and in Brazil.
- Understanding the epidemiological patterns of hepatitis mortality is crucial for targeted interventions.
Purpose of the Study:
- To analyze the spatial distribution and temporal trends of hepatitis mortality rates in Brazil from 2001 to 2020.
- To identify regional variations and temporal changes in hepatitis-related deaths.
Main Methods:
- Ecological study utilizing data from Brazil's Mortality Information System (SIM/DATASUS) from 2001-2020.
- Standardized mortality rates (SMR) were calculated and stratified by year, region, and municipality.
- Temporal trends were assessed using Prais-Winsten regression, and spatial distribution was analyzed with the Global Moran Index (GMI).
Main Results:
- Chronic viral hepatitis had the highest SMR (0.88/100,000), followed by Other viral hepatitis (0.22/100,000).
- Mortality rates for Hepatitis A, B, Other viral, and Unspecified Hepatitis showed significant decreasing temporal trends.
- Conversely, mortality due to chronic viral hepatitis demonstrated an increasing trend in the North (5.74%) and Northeast (4.95%) regions.
Conclusions:
- Hepatitis A, B, other viral, and unspecified hepatitis mortality trends are decreasing nationwide.
- A concerning increase in chronic viral hepatitis mortality is observed in Brazil's North and Northeast regions.
- Spatial analysis revealed significant clustering for all hepatitis types, highlighting regional disparities.
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