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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
402

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Personalized demand-responsive biphasic microneedle patch for smart drug administration.

Shuyue Deng1, Yao Shuai2, Shibo Zhang1

  • 1College of Pharmacy, China Pharmaceutical University, Nanjing 211198, China. jjdai@cpu.edu.cn.

Biomaterials Science
|July 5, 2023
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Summary

Microneedle patches (MNPs) with modifiable nanocontainers enable personalized drug delivery. This biphasic MNP design offers adjustable drug release durations for tailored chronic disease management.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Personalized medicine requires tailored drug regimens, particularly for chronic diseases.
  • Microneedle patches (MNPs) offer a promising platform for controlled drug delivery.
  • Current MNPs lack the ability to modulate treatment regimens within a single device.

Purpose of the Study:

  • To develop a novel MNP system capable of multiple, adjustable treatment regimens.
  • To functionalize MNPs with modifiable nanocontainers (NCs) for personalized dosing.
  • To evaluate the drug loading capacity, release kinetics, and in vivo performance of the developed MNPs.

Main Methods:

  • Fabrication of biphasic MNPs incorporating drug-loaded nanocontainers (NCs).
  • Characterization of drug loading capacity and in vitro drug release profiles (zero-order release for ≥20 days).
  • Generation of three MNP models (Type-A, Type-B, Type-C) simulating varied personalized dosing needs.
  • In vivo evaluation of therapeutic drug concentrations, duration of action (24-144 hours), and biocompatibility.

Main Results:

  • Biphasic MNPs exhibited approximately double the drug loading capacity compared to traditional dissolving MNPs.
  • Drug-loaded NCs demonstrated sustained zero-order release kinetics in vitro for over 20 days.
  • In vivo studies showed effective therapeutic drug concentrations within 12 hours and adjustable action durations.
  • The MNP system demonstrated outstanding biocompatibility in vivo.

Conclusions:

  • The developed MNP system, functionalized with modifiable NCs, successfully achieves multiple, adjustable treatment regimens.
  • This innovative biphasic MNP design offers enhanced drug loading and controlled, sustained release profiles.
  • The findings highlight the significant potential of this MNP technology for personalized drug delivery applications.