Related Experiment Video
Updated: Jul 24, 2025

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Tetranuclear Ru2Cu2 and Ru2Ni2 complexes with nanomolar anticancer activity
Andrés Alguacil1, Franco Scalambra1, Pablo Lorenzo-Luis2,3
1Área de Química Inorgánica-CIESOL, Universidad de Almería, 04120, Almería, Spain. romerosa@ual.es.
Abstract:
Complexes [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N'-CuCl}2-μ-Cl-μ-OCH3](CF3SO3)2·(CH3OH)4 (1) and [{RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2-N,N'-NiCl}2-μ-Cl-μ-OH](CF3SO3)2 (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI50 values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated.
More Related Videos
07:20Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
10:51The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015