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Association between Helicobacter pylori infection and metabolic syndrome and its components
Ying Liu1,2, Ping Shuai1,2, Wanjing Chen1,2
1Department of Health Management Center & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Background And Aim:
The association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) has been studied previously; however, the results remain controversial, which could be partly due to the different criteria used for defining MetS. We adopted five MetS criteria to provide better understanding of the association between H. pylori infection and MetS.
Methods:
Physical examination data of 100,708 subjects were obtained from January 2014 to December 2018. MetS was defined based on five criteria including: International Diabetes Federation (IDF), The Third Report of the National Cholesterol Education Program Expert Panel, Adult Treatment Panel III (ATP III), Joint Statement of International Multi-Societies (JIS), Chinese Diabetes Society (CDS), and the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2017 edition)(CDS DM). Multivariate logistic regression analysis was performed to elucidate the association between H. pylori infection and MetS and its components.
Results:
The prevalence of MetS defined assessed using IDF, ATP III, JIS, CDS and CDS DM criteria was 15.8%, 19.9%, 23.7%, 8.7% and 15.4%, respectively. In males, the prevalence of MetS assessed using the five criteria in H. pylori-positive group was higher than that in negative-group; however, in females, same results were obtained using the three international criteria. In males, the prevalence of all MetS components was found to be higher in the H. pylori-positive group than those in the negative group; however, in females, only the prevalence of dyslipidemia and waist circumferences exhibited significant differences. Multivariate logistic regression analysis revealed that H. pylori infection in males was positively correlated with MetS. Additionally, H. pylori infection was found to be positively correlated with the waist circumference in the general population, and with hypertension and hyperglycemia in males.
Conclusions:
H. pylori infection was found to be positively associated with MetS in males in China.
Insights
Helicobacter pylori infection is linked to metabolic syndrome in Chinese males. This study clarifies the association using multiple diagnostic criteria for metabolic syndrome.
Area of Science:
- Gastroenterology
- Public Health
- Epidemiology
Background:
- The relationship between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) is debated.
- Previous studies show conflicting results, potentially due to varied MetS diagnostic criteria.
Purpose of the Study:
- To investigate the association between H. pylori infection and MetS.
- To analyze this association using five distinct MetS diagnostic criteria.
Main Methods:
- Utilized physical examination data from 100,708 subjects (2014-2018).
- Defined MetS using International Diabetes Federation (IDF), ATP III, Joint Statement of International Multi-Societies (JIS), Chinese Diabetes Society (CDS), and CDS DM criteria.
- Employed multivariate logistic regression to analyze H. pylori infection's link to MetS and its components.
Main Results:
- MetS prevalence varied by criteria (IDF: 15.8% to JIS: 23.7%).
- H. pylori-positive males showed higher MetS prevalence and components (dyslipidemia, waist circumference, hypertension, hyperglycemia) than H. pylori-negative males.
- In females, H. pylori infection was associated with dyslipidemia and increased waist circumference.
Conclusions:
- H. pylori infection is positively associated with metabolic syndrome in males in China.
- The study highlights gender-specific associations and the impact of diagnostic criteria on MetS research.
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