Syncope and the Inability to Move: Was It the Magnesium?
David R Perkins1, Omar Kandah1, Larissa Check1
1Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA.
Cureus
|July 5, 2023
Summary
Proton pump inhibitors (PPIs) are effective for acid-related disorders but can cause severe electrolyte imbalances. Long-term PPI use, like with omeprazole, may lead to dangerous hypomagnesemia, requiring careful monitoring.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Proton pump inhibitors (PPIs) are widely used for acid-related gastrointestinal disorders.
- They function by irreversibly inhibiting gastric acid secretion via the (H+,K+)-ATPase enzyme.
Observation:
- A case report details a 68-year-old male experiencing syncope and profound weakness.
- The patient presented with undetectable magnesium levels attributed to long-term omeprazole use.
Findings:
- Long-term use of PPIs, including omeprazole, can lead to significant electrolyte disturbances.
- Profound hypomagnesemia is a potential, life-threatening complication of PPI therapy.
Implications:
- Clinicians must be vigilant for electrolyte derangements in patients on long-term PPIs.
- Regular electrolyte monitoring is crucial for patients undergoing PPI treatment to prevent adverse events.
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