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New insights on the interplays between m6A modifications and microRNA or lncRNA in gastrointestinal cancers

Tao Su1,2, Jiandong Liu3, Nasha Zhang4,5

  • 1Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Frontiers in Cell and Developmental Biology
|July 5, 2023
PubMed

Insights

N6-Methyladenosine (m6A) RNA modification influences cancer by affecting RNA metabolism. Targeting m6A-related long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) offers new gastrointestinal cancer treatment strategies.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • N6-Methyladenosine (m6A) is a prevalent RNA modification impacting RNA metabolism and gene expression.
  • Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are key regulators of biological processes at transcriptional and post-transcriptional levels.
  • Dysregulation of RNA metabolism is implicated in cancer development and progression.

Purpose of the Study:

  • To systematically review the intricate interplay between m6A modification and lncRNAs/miRNAs.
  • To elucidate the impact of these interactions on gastrointestinal cancer progression.
  • To highlight the therapeutic potential of targeting m6A-related ncRNAs in gastrointestinal cancers.

Main Methods:

  • Literature review and systematic summarization of existing research.
  • Analysis of studies investigating m6A modification in lncRNAs and miRNAs.
  • Examination of the role of m6A-modified ncRNAs in gastrointestinal cancer.

Main Results:

  • m6A modification influences the cleavage, stability, structure, transcription, and transport of lncRNAs and miRNAs.
  • ncRNAs modulate m6A levels by regulating m6A methyltransferases, demethylases, and binding proteins.
  • Interactions between m6A and ncRNAs significantly impact gastrointestinal cancer progression.

Conclusions:

  • Targeting m6A-related lncRNAs and miRNAs presents promising novel therapeutic avenues for gastrointestinal cancers.
  • Further research is warranted to fully elucidate the mechanisms and therapeutic potential.
  • Understanding these regulatory networks is crucial for advancing gastrointestinal cancer treatment.
Keywords:
RNA modificationlncRNAm6A modificationmicroRNAncRNA

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