Atherosclerosis treatment with nanoagent: potential targets, stimulus signals and drug delivery mechanisms

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Cardiovascular Medicine

Background:

• Cardiovascular diseases (CVDs) are the leading global cause of mortality, with atherosclerosis as a primary contributor.
• Conventional oral therapies for atherosclerosis face limitations such as low drug utilization and off-target organ toxicity.
• Micro-nano materials present a novel approach for CVDs detection and targeted drug delivery.

Purpose of the Study:

• To review the advancements in atherosclerosis nanotherapy.
• To explore the application of micro-nano materials for targeted drug delivery in atherosclerosis.
• To highlight the potential of intelligent and responsive nanomedicine for precision treatment of atherosclerosis.

Main Methods:

• Review of current literature on micro-nano materials for atherosclerosis treatment.
• Analysis of various material carriers, targeting strategies, and responsive models used in nanotherapy.
• Evaluation of treatment outcomes and efficacy of nanoagents in preclinical and clinical studies.

Main Results:

• Micro-nano materials, including particles, liposomes, micelles, and bubbles, show promise in targeting atherosclerotic lesions.
• Intelligent and responsive nanoagents enable precise drug release at target sites.
• Nanotherapy demonstrates potential for minimizing adverse effects and enhancing therapeutic outcomes in atherosclerosis.

Conclusions:

• Micro-nano materials represent a revolutionary tool for the precision treatment of atherosclerosis.
• Targeted drug delivery systems using nanoagents can significantly improve the efficacy of atherosclerosis therapy.
• Further research into atherosclerosis nanotherapy holds promise for overcoming the limitations of conventional treatments.