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Future Biomarkers for Infection and Inflammation in Rheumatoid Arthritis

Shuang Cui1, Jie Qian1

  • 1Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People's Republic of China.

Journal of Inflammation Research
|July 5, 2023
PubMed

Insights

Diagnosing infections in rheumatoid arthritis (RA) patients is challenging due to atypical symptoms. Novel biomarkers like presepsin and immune cell analysis offer improved accuracy in distinguishing infection from inflammation, guiding treatment decisions.

Area of Science:

  • Immunology
  • Rheumatology
  • Infectious Diseases

Background:

  • Rheumatoid arthritis (RA) compromises immune function, increasing infection susceptibility.
  • Differentiating infection from aseptic inflammation in RA patients is clinically challenging.
  • Current diagnostic markers lack specificity for bacterial infections in immunosuppressed individuals.

Purpose of the Study:

  • To review novel biomarkers for identifying infections in rheumatoid arthritis (RA) patients.
  • To discuss biomarkers capable of distinguishing infection from inflammation.
  • To highlight potential biomarkers for improved clinical decision-making in RA management.

Main Methods:

  • Literature review of novel biomarkers in RA patients with infection.
  • Analysis of biomarkers including presepsin, serology, haematology, neutrophils, T cells, and natural killer cells.
  • Discussion of biomarkers differentiating infection from inflammation.

Main Results:

  • Several novel biomarkers, including presepsin and immune cell profiles, show promise in identifying infections in RA.
  • These biomarkers offer potential to differentiate between infection and aseptic inflammation.
  • Current traditional markers are insufficient for accurate diagnosis in this population.

Conclusions:

  • Novel biomarkers are crucial for accurate and timely diagnosis of infections in RA patients.
  • Effective differentiation between infection and inflammation aids in appropriate treatment strategies.
  • Further development and validation of these biomarkers will enhance clinical practice for RA management.
Keywords:
T cellbiomarkerinfectioninflammationrheumatoid arthritis

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