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Updated: Jul 24, 2025
08:07
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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Functional role of MicroRNA/PI3K/AKT axis in osteosarcoma
Yubo Xiang1, Yingxin Yang1, Jia Liu1
1Department of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, China.
Frontiers in Oncology
|July 5, 2023
Summary
MicroRNAs (miRNAs) regulate the PI3K/AKT pathway, crucial in osteosarcoma (OS) development. This pathway-associated miRNA/PI3K/AKT axis offers potential biomarkers for OS diagnosis and treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Osteosarcoma (OS) is a primary bone cancer predominantly affecting children and adolescents.
- Overactivation of the PI3K/AKT pathway is a common hallmark in OS patients.
- MicroRNAs (miRNAs) are key regulators of gene expression and are implicated in cellular functions.
Purpose of the Study:
- To review the role of the PI3K/AKT pathway and the miRNA/PI3K/AKT axis in osteosarcoma development.
- To explore the clinical applications of these molecular pathways as biomarkers for OS.
- To summarize recent research advances in this field.
Main Methods:
- Literature review of recent research on miRNA, PI3K/AKT pathway, and osteosarcoma.
- Analysis of the regulatory mechanisms of the miRNA/PI3K/AKT axis in cancer progression.
- Examination of the association between PI3K/AKT pathway-associated miRNAs and clinical features of OS.
Main Results:
- The PI3K/AKT pathway is frequently overactivated in osteosarcoma.
- MiRNAs play a significant role in regulating the PI3K/AKT pathway and cellular functions in OS.
- The miRNA/PI3K/AKT axis influences osteosarcoma-related gene expression and cancer progression.
Conclusions:
- The miRNA/PI3K/AKT axis is integral to osteosarcoma pathogenesis.
- MiRNAs associated with the PI3K/AKT pathway are potential diagnostic and prognostic biomarkers for osteosarcoma.
- Targeting the miRNA/PI3K/AKT axis may offer novel therapeutic strategies for osteosarcoma.
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