Hypopituitarism After Mild Traumatic Brain Injury: A Case Report

Area of Science:

• Neuroendocrinology
• Trauma Science

Background:

• Hypopituitarism, a condition of an underactive pituitary gland, can manifest as hormone deficiencies.
• Traumatic brain injury (TBI) is a recognized risk factor for developing hypopituitarism.
• Subtle signs and symptoms of hypopituitarism may lead to delayed diagnosis, particularly after TBI.

Observation:

• A 40-year-old male US military veteran reported fatigue, sexual dysfunction, and weight gain years after multiple mild TBIs.
• Previous diagnosis of hypothyroidism was noted.
• A comprehensive neuroendocrine evaluation was performed.

Findings:

• The neuroendocrine workup revealed testosterone deficiency.
• The patient had previously diagnosed hypothyroidism.
• Symptoms resolved following the initiation of testosterone therapy.

Implications:

• This case highlights the importance of considering hypopituitarism in individuals with a history of TBI, especially military veterans.
• Subtle neuroendocrine changes post-TBI may require thorough investigation.
• Testosterone replacement therapy can effectively manage hypopituitarism symptoms secondary to TBI.