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Systemic Immune-Inflammation Index Predicts Prolonged Mechanical Ventilation and Intensive Care Unit Stay After

I Made Adi Parmana1, Cindy Elfira Boom1, Herdono Poernomo1

  • 1Department of Anesthesiology and Intensive Care, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.

Vascular Health and Risk Management
|July 5, 2023
PubMed

Insights

High systemic immune-inflammation index (SII) predicts longer recovery after off-pump coronary artery bypass grafting (OPCAB) surgery. Elevated SII indicates increased risk for prolonged ventilation and ICU stay, crucial for patient management.

Area of Science:

  • Cardiovascular Surgery
  • Inflammatory Markers
  • Surgical Outcomes

Background:

  • Coronary artery disease (CAD) is a leading cause of death globally.
  • Off-pump coronary artery bypass grafting (OPCAB) minimizes trauma but can still trigger systemic inflammation.
  • Predictive markers for perioperative outcomes in OPCAB are crucial.

Purpose of the Study:

  • To evaluate the prognostic value of the systemic immune-inflammation index (SII) in patients undergoing OPCAB.
  • To determine if preoperative SII predicts adverse perioperative outcomes after OPCAB surgery.

Main Methods:

  • Retrospective single-center study of 371 patients who underwent OPCAB surgery.
  • SII calculated from preoperative neutrophil, lymphocyte, and platelet counts.
  • Patients stratified into high (≥878.057 x 10³ /mm³) and low SII groups.

Main Results:

  • 17% of patients had high preoperative SII values.
  • High SII significantly predicted prolonged mechanical ventilation (RR 1.141) and intensive care unit (ICU) stay (RR 1.218).
  • A positive correlation was found between SII and hospital length of stay.

Conclusions:

  • Preoperative SII is a significant predictor of prolonged mechanical ventilation and ICU stay post-OPCAB.
  • Elevated SII may indicate increased inflammatory response and poorer recovery.
  • SII can aid in risk stratification and management of OPCAB patients.
Abstract

Keywords:
intensive care unit staymechanical ventilationoff-pump coronary artery bypass graftsystemic immune-inflammation indexsystemic inflammation

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