Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How Collaboration Between Surgeons and Medical Oncologists Affects Outcomes for Patients with Pancreatic Cancer.

Joint Commission journal on quality and patient safety·2026
Same author

Bone mineral density outcomes after parathyroidectomy in primary hyperparathyroidism and osteopenia: A meta-analysis and metaregression.

Surgery·2026
Same author

Implementation of virtual parental presence during induction of anesthesia: a single-site descriptive study at a pediatric academic center.

BMC anesthesiology·2026
Same author

Increase in Necrotizing Enterocolitis with Cessation of Bifidobacteriumlongum ssp. infantis Administration in Very Low Birthweight Infants: A Single Center Retrospective Cohort Study.

The Journal of pediatrics·2025
Same author

Iron Deficiency Associated Thrombocytosis May Reach Very High Levels in Children and Usually Shows Inverse Correlation with Hemoglobin and MCV: Report of a Pediatric Case and a Brief Literature Review.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2025
Same author

Evaluating the role of postoperative long-acting somatostatin analog therapy in patients with metastatic neuroendocrine tumors undergoing surgical debulking.

Surgery·2025

Related Experiment Video

Updated: Jul 24, 2025

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

717

Establishing Pediatric Reference Ranges for Rotational Thromboelastometry.

Erin Kathleen Goodhue Meyer1, Joshua Uffman2, Stephanie Townsend1

  • 1Department of Pathology and Lab Medicine, Transfusion Service, Nationwide Children's Hospital, Columbus, OH, USA.

American Journal of Clinical Pathology
|July 5, 2023
PubMed
Summary

This study established normal pediatric reference intervals for rotational thromboelastometry (ROTEM) Delta assays in children. These new age-specific ranges aid clinicians in making informed transfusion decisions for pediatric patients.

Keywords:
CoagulationPediatricRotational thromboelastometryTransfusion

More Related Videos

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

6.9K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.3K

Related Experiment Videos

Last Updated: Jul 24, 2025

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

717
Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

6.9K
A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

17.3K

Area of Science:

  • Pediatric Hematology
  • Hemostasis and Thrombosis
  • Clinical Pathology

Background:

  • Accurate interpretation of rotational thromboelastometry (ROTEM) Delta assays in children requires age-specific reference intervals.
  • Existing reference ranges are often based on adult data, potentially leading to misinterpretation in pediatric populations.

Purpose of the Study:

  • To establish normal pediatric reference intervals (PRIs) for ROTEM Delta assays (EXTEM, INTEM, FIBTEM).
  • To cover a wide pediatric age range from 0 to 18 years.
  • To facilitate accurate interpretation of coagulation status in children.

Main Methods:

  • Prospective study involving healthy pediatric patients undergoing elective minor surgery.
  • Sampled 20 patients per sex across 5 age groups (0-6 months, 6-12 months, 1-5 years, 5-11 years, 11-18 years).
  • ROTEM Delta assays (EXTEM, INTEM, FIBTEM) were performed.

Main Results:

  • Two sets of ROTEM PRIs were defined: one for children 11 years or younger and another for those older than 11 years.
  • PRIs for younger children were derived from the 2.5th and 97.5th percentiles of the 0-11 age groups.
  • Adult reference intervals were validated for children older than 11 years.

Conclusions:

  • Established age-specific ROTEM PRIs for pediatric patients.
  • Integrated these PRIs into the electronic medical record for clinical use.
  • Improved interpretation of ROTEM results and informed transfusion decisions in children.