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Role of developmental pathways in disease
1Developmental and Stem Cell Biology Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Canada.
The FEBS Journal
|July 5, 2023
Summary
Disrupted developmental pathways, crucial for organism formation, can cause diseases when reactivated abnormally. This collection explores signaling pathways linked to both normal development and human disease.
Area of Science:
- Molecular Biology
- Developmental Biology
- Cell Signaling
Background:
- Developmental programs rely on regulated molecular and cellular signaling pathways for tissue and organ formation.
- Aberrant reactivation of these pathways, due to genetic or environmental factors, can lead to disease.
Discussion:
- Disrupted developmental pathways contribute to abnormal cell growth, differentiation, and migration.
- These disruptions result in structural abnormalities and functional impairments at tissue and organismal levels.
Key Insights:
- Signaling pathways essential for normal development are frequently deregulated in human diseases.
- Understanding these deregulated pathways is key to identifying disease mechanisms.
Outlook:
- This collection provides comprehensive reviews and research on developmental pathways in disease.
- Further research into these pathways can illuminate therapeutic strategies for various human conditions.
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