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Broadly neutralizing antibodies: "The next thing" to treat children with HIV?

Maud Mavigner1,2,3, Ann Chahroudi1,2,3

  • 1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Science Translational Medicine
|July 5, 2023
PubMed

Insights

Monthly infusions of two neutralizing antibodies kept HIV suppressed in about half of children who had early antiretroviral treatment.

Area of Science:

  • Immunology
  • Virology
  • Pediatric Infectious Diseases

Background:

  • Early antiretroviral treatment (ART) is crucial for managing pediatric HIV.
  • Long-term HIV suppression strategies beyond daily ART are needed.

Purpose of the Study:

  • To evaluate the efficacy of monthly infusions of two neutralizing antibodies for maintaining HIV suppression in children previously treated early with ART.

Main Methods:

  • A study involving children who received early antiretroviral treatment.
  • Monthly administration of two specific neutralizing antibodies.

Main Results:

  • HIV suppression was maintained in nearly 50% of the children during the study period.
  • This indicates a potential alternative or adjunctive approach to long-term HIV management.

Conclusions:

  • Monthly neutralizing antibody treatment can maintain HIV suppression in a significant proportion of children with a history of early ART.
  • Further research is warranted to optimize antibody-based strategies for pediatric HIV remission.

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