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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

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Published on: December 28, 2017

Candida auris Genetics and Emergence.

Anuradha Chowdhary^1,2, Kusum Jain¹, Neeraj Chauhan³

¹Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India;

Annual Review of Microbiology

|July 5, 2023

Summary

Candida auris is a multidrug-resistant fungus causing global health threats. This review examines its spread, drug resistance, and genome to inform strategies against this emerging pathogen.

Keywords:

MAP kinase signaling amphotericin B antifungal drug resistance azoles cell wall echinocandin

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Area of Science:

Medical Mycology
Infectious Diseases
Public Health

Background:

Candida auris is a multidrug-resistant fungal pathogen identified in 2009.
It has spread globally, causing high mortality rates (30-60%) and healthcare outbreaks.
C. auris exhibits resistance to all major antifungal drug classes, posing a significant clinical challenge.

Purpose of the Study:

To explore the reasons behind the rapid global dissemination of Candida auris.
To detail the genome organization and drug resistance mechanisms of C. auris.
To propose future research directions for controlling C. auris spread.

Main Methods:

Literature review of published studies on Candida auris.
Analysis of genomic data and drug resistance profiles.
Synthesis of current knowledge and identification of research gaps.

Main Results:

Candida auris demonstrates efficient transmission, particularly in healthcare settings.
It possesses significant and often untreatable resistance to azoles, amphotericin B, and echinocandins.
Understanding its genome is crucial for deciphering resistance mechanisms.

Conclusions:

Candida auris represents a serious and growing threat to global health due to its multidrug resistance and transmissibility.
Further research into its genome and resistance mechanisms is essential for developing effective treatments and control strategies.
Interdisciplinary efforts are needed to curb the spread of this resilient fungal pathogen.