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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy V: Interprofessional Care01:29

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy II: Dilated Cardiomyopathy01:30

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Imbalances in Cardiac Output01:26

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The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

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Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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Myocardial Work in Apical Hypertrophic Cardiomyopathy.

Matthew Peters1, M Fuad Jan1, Muddasir Ashraf1

  • 1Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Advocate Aurora Health, Milwaukee, Wisconsin.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|July 5, 2023
PubMed
Summary
This summary is machine-generated.

Myocardial work indices are impaired in apical hypertrophic cardiomyopathy (ApHCM) patients compared to non-ApHCM. These indices correlate with clinical factors but are less predictive of cardiac fibrosis in ApHCM.

Keywords:
Apical aneurysmApical hypertrophic cardiomyopathyCardiac magnetic resonance imagingEchocardiographyMyocardial work

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Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Imaging

Background:

  • Pressure-strain loop analysis is an emerging echocardiographic method for assessing myocardial work.
  • Its application in apical hypertrophic cardiomyopathy (ApHCM) remains unexplored.
  • This study investigates myocardial work indices in ApHCM versus non-ApHCM patients.

Purpose of the Study:

  • To compare myocardial work indices between ApHCM and non-ApHCM patients.
  • To explore associations between myocardial work indices and clinical variables.
  • To examine the relationship between myocardial work indices and late gadolinium enhancement (LGE) on cardiac MRI.

Main Methods:

  • Retrospective analysis of 48 ApHCM and 69 non-ApHCM patients.
  • Measurements included global longitudinal strain (GLS), global work index (GWI), global constructive work (GCW), and global work efficiency.
  • Cardiac MRI data were analyzed for 34 ApHCM and 51 non-ApHCM patients.

Main Results:

  • ApHCM patients showed significantly impaired GLS, GWI, and GCW compared to non-ApHCM patients.
  • Reduced GWI and GCW in ApHCM correlated with elevated N-terminal pro-b-type natriuretic peptide, abnormal troponin, and increased left ventricular wall thickness.
  • Global constructive work had modest accuracy for predicting LGE in ApHCM, while GLS was a strong predictor in non-ApHCM.

Conclusions:

  • Myocardial work indices are significantly impaired in ApHCM patients.
  • These indices correlate with key clinical variables in ApHCM.
  • Global longitudinal strain, GWI, and GCW are less predictive of cardiac fibrosis in ApHCM than in non-ApHCM.