Related Experiment Video
Updated: Jul 24, 2025
08:27
Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
11.0K
Systemic capillary leak syndrome secondary to decompression sickness
Akshay Mathavan1, Akash Mathavan2, Kirk Jones2
1Internal Medicine, University of Florida, Gainesville, Florida, USA amathavan1996@ufl.edu.
BMJ Case Reports
|July 5, 2023
Summary
Systemic capillary leak syndrome (SCLS) is a rare condition. This case report highlights a rare trigger: decompression sickness from deep diving, and suggests terbutaline and fluid resuscitation for management.
Area of Science:
- Vascular biology and endothelial function.
- Rare diseases and medical emergencies.
- Diving medicine and hyperbaric physiology.
Background:
- Systemic capillary leak syndrome (SCLS) is a rare endothelial dysfunction causing plasma and protein leakage.
- SCLS can be primary (unknown cause) or secondary to inflammatory/infectious conditions.
- Decompression sickness is a very rare potential trigger for SCLS.
Observation:
- This report details a case of SCLS secondary to decompression sickness after deep diving.
- Physicians are alerted to this rare but potential complication.
- No definitive pharmacological treatment for acute SCLS is established.
Findings:
- Judicious fluid resuscitation demonstrated a positive response in managing acute SCLS.
- An oral cyclic AMP-elevating agent, terbutaline, also showed a positive response.
- These findings suggest potential therapeutic avenues for SCLS management.
Implications:
- Increased physician awareness of SCLS as a complication of decompression sickness is crucial.
- Early recognition and management may improve patient outcomes.
- Further research into SCLS triggers and effective treatments is warranted.
Related Concept Videos
01:25Pleural Effusion I: Introduction
1.3K
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
1.3K
01:26Heart Failure III: Clinical Manifestations
24
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
24
01:30Acute Respiratory Failure-III
228
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
228
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
14
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
14
01:26Pneumothorax-I
257
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
257
01:24Nephrotic Syndrome I : Introduction
9
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
9