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Iron oxide nanoparticle-based nanocomposites in biomedical application.
Yuyun Yang1, Yuejun Liu1, Laiming Song1
1Institute of Corrosion Science and Surface Technology, Department of Material Science and Chemical Engineering, Harbin Engineering University, Harbin, 15001, China.
Trends in Biotechnology
|July 5, 2023
Summary
Iron oxide nanoparticles (FeONPs) show promise for MRI and cancer therapy but face limitations due to poor design. Tailored FeONP nanocomposites offer improved functionality for biomedical applications, pending rigorous biosafety evaluation.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Iron-oxide-based biomagnetic nanocomposites have been used in MRI and cancer treatment for decades.
- Clinical applications are limited by adverse effects stemming from suboptimal material design, leading to agglomeration and reduced functionality.
Purpose of the Study:
- To address limitations in iron oxide nanoparticle (FeONP)-based nanocomposites for enhanced biomedical applications.
- To explore synthesis and modification strategies for tailoring FeONP properties.
Main Methods:
- Utilized various synthesis methods and modification strategies.
- Tailored size, shape, and properties of iron oxide nanoparticle (FeONP)-based nanocomposites.
Main Results:
- Modified nanocomposites demonstrate improved properties compared to conventional designs.
- Potential applications identified in diagnostics, therapeutics, and theranostics, including MRI, drug delivery, and anticancer/antimicrobial activity.
Conclusions:
- Tailored FeONP nanocomposites offer significant potential for biomedical applications.
- Rigorous biosafety evaluation is crucial for the clinical translation of these advanced nanomaterials.
