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High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
Published on: October 31, 2012
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[Posttransplant complications: GVHD and SOS/VOD]
1Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science.
Summary
Novel agents in allogeneic hematopoietic cell transplantation (HCT) may reduce relapse but increase risks of graft-versus-host disease (GVHD) and sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD). This review assesses managing these complications.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Novel agents like targeted drugs and cell therapies are increasingly used in allogeneic hematopoietic cell transplantation (allo-HCT).
- These therapies aim to improve outcomes by reducing pre-transplant tumors and preventing post-transplant relapse.
- Graft-versus-host disease (GVHD) and sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) are significant post-allo-HCT complications.
Conclusions:
- Careful risk assessment and management are crucial when using novel agents in allo-HCT.
- Strategies to mitigate GVHD and SOS/VOD are essential for improving patient outcomes.
- Ongoing research into novel agents and supportive care is vital for advancing allo-HCT.
Keywords:
Allogeneic stem cell transplantationGraft-versus-host diseaseMolecularly targeted therapySinusoidal obstruction syndrome/veno-occlusive diseaseMore Related Videos
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