Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.0K
Sex-linked Disorders01:43

Sex-linked Disorders

102.4K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.4K
Pleiotropy01:33

Pleiotropy

40.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.7K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

6.4K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.4K
Infertility in Males01:23

Infertility in Males

299
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
299
Confounding in Epidemiological Studies01:27

Confounding in Epidemiological Studies

191
Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
191

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypoxia-Cytokine Preconditioning Reduces Senescence and Improves Immunomodulatory and Tissue Repair Capabilities of UC-MSCs.

Current stem cell research & therapy·2026
Same author

The application of low-carbohydrate diet in autoimmune diseases: Mechanisms, evidence, and prospects for clinical translation.

Autoimmunity reviews·2026
Same author

Association of Th17/Treg immune imbalance and cardiovascular complications in RA patients: retrospective cohort study in refractory subgroups.

Clinical rheumatology·2025
Same author

Shen Yuan Yi Qi Huo Xue capsules inhibit neutrophil NETosis by regulating the PAD4/NLRP3 signaling pathway to prevent heart failure after myocardial infarction.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025
Same author

Gut microbiota in rheumatoid arthritis: Mechanistic insights, clinical biomarkers, and translational perspectives.

Autoimmunity reviews·2025
Same author

Mendelian randomization unveils genetic causal relationships between viral infections and systemic sclerosis.

Scientific reports·2025

Related Experiment Video

Updated: Jul 24, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

14.9K

Causal association between JAK2 and erectile dysfunction: a Mendelian randomization study.

Yu-Jia Xi1,2,3, Rui Wen2,3, Ran Zhang2,3

  • 1Department of Urology, Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, P.R. China.

Basic and Clinical Andrology
|July 5, 2023
PubMed
Summary
This summary is machine-generated.

Janus kinase 2 (JAK2) is causally linked to erectile dysfunction. Targeting JAK2 signaling may offer new therapeutic strategies for treating erectile dysfunction.

Keywords:
Dysfonction érectileErectile dysfunctionJAK2Mendelian randomizationRandomisation mendélienne

More Related Videos

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

613
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

37.6K

Related Experiment Videos

Last Updated: Jul 24, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

14.9K
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

613
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
07:21

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Published on: September 28, 2015

37.6K

Area of Science:

  • Biochemistry
  • Genetics
  • Urology

Background:

  • Janus kinase 2 (JAK2) is a key protein in the JAK/STAT signaling pathway, implicated in various biological processes and diseases.
  • Observational studies suggest a role for JAK2 in erectile dysfunction, but a causal link remains unestablished.

Purpose of the Study:

  • To investigate the potential causal relationship between Janus kinase 2 (JAK2) and erectile dysfunction using genetic evidence.

Main Methods:

  • Utilized Mendelian randomization analysis with inverse variance weighting and weighted median methods.
  • Assessed for heterogeneity using Cochran's Q-test and MR-PRESSO.
  • Evaluated for pleiotropy to ensure the reliability of genetic associations.

Main Results:

  • Genetically predicted JAK2 showed a significant causal association with erectile dysfunction (OR = 1.109, P = 0.007).
  • Robust findings were confirmed using the weighted median method (OR = 1.117, P = 0.044).
  • No significant heterogeneity (P = 0.855) or pleiotropy (P = 0.617) was detected.

Conclusions:

  • Janus kinase 2 (JAK2) is identified as a risk factor for erectile dysfunction.
  • Establishes a causal link between JAK2 and erectile dysfunction.
  • Suggests that targeting JAK2 signaling pathways could be a promising therapeutic approach for erectile dysfunction.