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Glycyrrhiza polysaccharides inhibits PRRSV replication
Youbing Yang1,2, Yongjian Liu1,2, Ran Lou1,2
1College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471023, China.
Virology Journal
|July 5, 2023
Summary
Glycyrrhiza polysaccharide (GCP) shows antiviral activity against porcine reproductive and respiratory syndrome virus (PRRSV). GCP inhibits PRRSV replication and modulates key gene expression, suggesting its potential as a PRRS treatment.
Area of Science:
- Veterinary Virology
- Natural Product Chemistry
- Immunology
Background:
- Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses in the global swine industry.
- PRRSV is characterized by high genetic variability and poses a continuous challenge for disease control.
- Traditional Chinese medicine components are explored for novel antiviral therapies.
Purpose of the Study:
- To investigate the antiviral efficacy of Glycyrrhiza polysaccharide (GCP) against PRRSV.
- To elucidate the molecular mechanisms underlying GCP's antiviral action.
- To evaluate GCP as a potential therapeutic agent for PRRS.
Main Methods:
- In vitro assessment of GCP's effect on PRRSV replication.
- Quantitative real-time PCR (qRT-PCR) to analyze mRNA expression of host genes.
- Dose-response analysis of GCP's antiviral activity.
Main Results:
- GCP demonstrated a dose-dependent inhibition of PRRSV replication.
- GCP significantly downregulated the mRNA expression of PRRSV receptor genes CD163 and NF-κB p65.
- GCP promoted the mRNA expression of the SLA-7 gene.
Conclusions:
- GCP exhibits potent antiviral activity against PRRSV.
- The mechanism involves modulation of host cellular receptors and inflammatory pathways.
- GCP is a promising candidate for the prevention and treatment of PRRS.
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