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Related Experiment Video

Updated: Jul 24, 2025

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay

Published on: June 16, 2021

Female BMI has an effect on oocyte gene expression pattern.

Zhiren Liu^1,2,3, Mingting Jiang⁴, Xingting Chen¹

¹Center for Reproductive Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

|July 6, 2023

Summary

Abnormal female body mass index (BMI) impacts oocyte quality by altering gene expression. Higher BMI (≥25 kg/m²) may enhance oocyte resilience to stress, potentially improving embryo quality in assisted reproductive technology (ART) cycles.

Keywords:

Clinical outcome Female BMI Gene expression pattern Intracytoplasmic sperm injection Oocyte

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Last Updated: Jul 24, 2025

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay

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Published on: June 16, 2021

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

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Published on: April 10, 2018

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

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Published on: May 6, 2022

Area of Science:

Reproductive Science
Genomics
Infertility Research

Background:

Female obesity is linked to reduced oocyte quality and ART success rates.
The specific molecular mechanisms by which body mass index (BMI) influences oocyte quality remain incompletely understood.
Investigating gene expression patterns offers insight into how BMI affects oocyte biology.

Purpose of the Study:

To elucidate the mechanisms linking abnormal female BMI to altered oocyte quality.
To determine if altered gene expression patterns mediate the impact of BMI on oocytes.
To correlate these molecular changes with clinical outcomes in assisted reproduction.

Main Methods:

Retrospective clinical outcome analysis comparing women with BMI ≥25 kg/m² and BMI ≤20 kg/m².
Transcriptome analysis utilizing the GSE87201 dataset to compare oocyte gene expression.
Correlation of gene expression profiles with clinical data from intracytoplasmic sperm injection (ICSI) cycles.

Main Results:

A significantly higher rate of grade 1-2 embryos on day 3 was observed in women with BMI ≥25 kg/m² compared to those with BMI ≤20 kg/m².
Oocytes from women with BMI ≥25 kg/m² exhibited gene expression patterns suggesting enhanced tolerance to exogenous stress, such as ICSI.
These molecular findings provide a potential explanation for the improved day-3 embryo quality in the higher BMI group.

Conclusions:

Abnormal female BMI influences oocyte quality through modifications in oocyte gene expression.
Despite known risks, a BMI ≥25 kg/m² may confer specific advantages to oocytes, enhancing their resilience.
Understanding these BMI-mediated gene expression changes is crucial for optimizing ART outcomes.