Related Experiment Video
Updated: Jul 24, 2025
05:32
Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
Published on: February 21, 2025
338
Ex vivo coronary calcium volume quantification using a high-spatial-resolution clinical photon-counting-detector
Jeffrey F Marsh1, Patrick D VanMeter1, Kishore Rajendran1
1Mayo Clinic, Department of Radiology, Rochester, Minnesota, United States.
Journal of Medical Imaging (Bellingham, Wash.)
|July 6, 2023
Summary
Ultra-high-resolution photon-counting detector (PCD) CT improves coronary artery calcification (CAC) volume accuracy by reducing blooming artifacts. This advanced CT technology offers superior quantification compared to conventional methods.
Area of Science:
- Medical Imaging
- Radiology
- Cardiovascular Disease
Background:
- Coronary artery calcification (CAC) is a key indicator of coronary heart disease.
- Accurate CAC volume quantification is crucial for risk assessment but challenging due to calcium blooming artifacts in conventional computed tomography (CT).
- Calcium blooming, caused by limited spatial resolution, leads to overestimation of CAC volume.
Purpose of the Study:
- To evaluate the accuracy of CAC volume estimation using an ultra-high-resolution (UHR) clinical photon-counting detector (PCD) CT scanner.
- To compare the performance of UHR clinical PCD-CT with conventional energy-integrating detector (EID) CT, a previous-generation investigational PCD-CT, and micro-CT.
Main Methods:
- Ex vivo coronary specimens were scanned using EID-CT and UHR clinical PCD-CT with matched parameters.
- Images were reconstructed using standard clinical protocols and sharper kernels with denoising for PCD-CT.
- Micro-CT served as the reference standard for volume quantification; calcification volumes were segmented and compared across modalities.
Main Results:
- Clinical UHR PCD-CT demonstrated significantly lower mean absolute percent error in CAC volume estimation compared to EID-CT and previous-generation PCD-CT (p < 0.001).
- Mean calcification CT number and contrast-to-noise ratio were significantly higher with clinical UHR PCD-CT versus EID-CT (p < 0.001).
- The UHR clinical PCD-CT achieved a mean absolute percent error of [insert value from abstract] compared to micro-CT.
Conclusions:
- Ultra-high-resolution clinical photon-counting detector CT significantly reduces calcium blooming artifacts.
- This advanced CT technology enables more accurate CAC volume quantification than conventional EID-CT and earlier PCD-CT systems.
- UHR clinical PCD-CT represents a substantial advancement for precise assessment of coronary artery calcification.
Keywords:
calcium quantificationcoronary artery diseasecoronary calcificationsimage domain denoisingphoton counting detector computed tomographyMore Related Videos
10:16Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
Published on: February 10, 2012
32.6K
06:57Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
1.0K
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
42
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
42
01:28Imaging Studies for Cardiovascular System V: CT
45
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
45
01:10Computed Tomography
4.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.6K
01:27Imaging Studies III: Computed Tomography
29
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
29
01:20Imaging Studies for Cardiovascular System III: X-Ray
219
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
219