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Updated: Jul 24, 2025

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Sentinel node mapping in thyroid cancer: an overview.

Marco Puccini^1,2, Carlo Enrico Ambrosini², Leonardo Rossi¹

¹Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

Frontiers in Medicine

|July 6, 2023

Summary

This summary is machine-generated.

Sentinel node mapping (SNM) in thyroid tumors shows promise for detecting hidden lymph node metastases in both papillary and medullary thyroid cancers. However, its clinical significance requires further investigation through large randomized trials.

Keywords:

indocyanine green lymph node dissection medullary thyroid cancer papillary thyroid cancer radioguide sentinel lymph node thyroid cancer

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Area of Science:

Oncology
Surgical Pathology
Nuclear Medicine

Background:

Sentinel node mapping (SNM) has been explored for thyroid tumors since the late 20th century.
It is primarily investigated in papillary thyroid cancer (PTC) and medullary thyroid cancer (MTC).

Purpose of the Study:

To review the current status and future potential of SNM in thyroid cancer.
To evaluate SNM's effectiveness in identifying occult lymph node metastases.

Main Methods:

Review of existing studies on SNM techniques in PTC and MTC.
Analysis of SNM's success in detecting sentinel nodes in the central and lateral neck compartments.

Main Results:

SNM methods have demonstrated effectiveness in identifying sentinel nodes for both PTC and MTC.
The clinical significance of detected occult metastases in differentiated thyroid cancer and MTC remains uncertain.

Conclusions:

SNM is an experimental methodology for thyroid tumors, lacking robust evidence from randomized controlled trials.
Emerging technologies may facilitate future studies to clarify the clinical impact of occult neck metastases.