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Two infants experienced near-miss sudden infant death syndrome events and seizures after caffeine. This suggests caffeine may lower the seizure threshold in infants with apnea and seizure disorders.
Area of Science:
- Neonatal neurology
- Pediatric critical care
Background:
- Sudden Infant Death Syndrome (SIDS) remains a concern.
- Apnea is a common symptom in infants presenting with SIDS events.
Observation:
- Two infants experienced near-miss SIDS events.
- These infants developed seizure disorders following caffeine administration.
Findings:
- Caffeine treatment may be associated with the onset of seizures in infants with near-miss SIDS.
- A subgroup of infants with near-miss SIDS and apnea may have a lowered seizure threshold.
Implications:
- Central nervous system stimulants like caffeine might precipitate seizures in susceptible infants.
- Further research is needed to identify infants at risk for caffeine-induced seizures.
Abstract:
We report two infants with near miss sudden infant death syndrome events exhibiting seizure disorders after caffeine treatment, suggesting there is an infant subgroup diagnosed as near miss sudden infant death syndrome who have apnoea possibly with seizures whose seizure threshold may be lowered by central nervous system stimulants like caffeine.