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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jul 24, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

Microphysiological Systems for Cancer Immunotherapy Research and Development.

Yansong Peng¹, Esak Lee¹

¹Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.

Advanced Biology

|July 6, 2023

Summary

This summary is machine-generated.

Microfluidic organ-on-a-chip systems offer a promising avenue for personalized cancer immunotherapy by enabling faster screening and better understanding of tumor-immune interactions. These advanced models aim to overcome current treatment resistance and improve patient outcomes.

Keywords:

engineered T cell therapy immune checkpoint blockade immunotherapy microphysiological system tumor immune microenvironment

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Area of Science:

Biomedical Engineering
Cancer Research
Immunology

Background:

Cancer immunotherapy leverages the patient's immune system to fight cancer, with numerous FDA-approved treatments available.
Despite advancements, many patients exhibit resistance to current immunotherapies due to tumor genetic heterogeneity and the complex tumor immune microenvironment.
Existing drug screening methods face limitations in accurately reflecting in vivo conditions.

Purpose of the Study:

To review recent advancements in microphysiological organ-on-a-chip (OOC) systems for cancer immunity research.
To highlight the application of OOC technology in testing cancer immunotherapeutic agents.
To discuss the challenges and potential of translating OOC technology to clinical applications in personalized immunotherapy.

Main Methods:

Review of cutting-edge microphysiological OOC devices developed for cancer immunity studies.
Analysis of OOC systems for screening personalized immunotherapies.
Examination of OOC models for understanding tumor-immune interactions.

Main Results:

OOC technologies provide a more realistic 3D microenvironment for studying cancer immunity.
These systems offer improved controllability, reproducibility, and physiological relevance compared to traditional methods.
OOC platforms facilitate patient-specific screening for immunotherapy and investigation of tumor-immune dynamics.

Conclusions:

Microfluidic OOC systems represent a significant advancement in cancer research and drug development.
These technologies hold great potential for overcoming immunotherapy resistance and enabling personalized medicine approaches.
Further development is needed to address challenges in clinical translation for widespread immunotherapy applications.