Histological changes in the vaginal connective tissue of patients with and without uterine prolapse

The histological structure of the vaginal fascia was studied in two groups of patients: 10 consecutive women having a vaginal repair for uterine prolapse or descent and 10 consecutive women having an abdominal hysterectomy for fibroids. Abnormal histological changes were found in 7 out of 10 patients with uterine descent as compared to 2 out of 10 controls (P less than 0.05). This suggests a correlation between histological changes in vaginal connective tissue and pelvic laxity.