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Related Experiment Videos

Increase in cardiac output with rate-responsive pacemaker.

F Beyersdorf, J Kreuzer, T A Happ

    The Annals of Thoracic Surgery
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Respiratory-dependent pacemakers (RDPs) effectively increase heart rate and cardiac output during exercise in patients with myocardial insufficiency. This technology offers a reliable alternative to VVI pacemakers when dual-chamber pacing is contraindicated.

    Area of Science:

    • Cardiology
    • Biomedical Engineering
    • Medical Devices

    Background:

    • Patients with myocardial insufficiency or high cardiac workload rely on increased heart rate (HR) for cardiac output (CO).
    • VVI pacemakers limit HR increase, potentially compromising CO during exertion.
    • Respiratory-dependent pacemakers (RDPs) offer a mode to potentially increase HR and CO.

    Purpose of the Study:

    • To test the hypothesis that RDPs can increase cardiac output (CO) by increasing heart rate (HR).
    • To compare the efficacy of RDPs versus VVI pacing in managing cardiac function during exercise.

    Main Methods:

    • A clinical study involving 21 patients implanted with a multiprogrammable RDP.
    • Patients served as their own controls, being tested in both RDP and VVI modes.

    Related Experiment Videos

  • Exercise electrocardiography (ECG) and equilibrium-radionuclide ventriculography were used to determine CO at rest and during exercise.

    • Main Results:

    • A significant increase in HR was observed during exercise with RDP compared to VVI mode (105.5 bpm vs. 84.5 bpm; p < 0.05).
    • Cardiac output (CO) increased during exercise in RDP mode (12.7 L/min) compared to VVI mode (10.6 L/min), showing a 26-35% improvement.
    • RDPs demonstrated reliability, with only one device explanted due to end-of-life; no other malfunctions occurred.

    Conclusions:

    • RDPs are reliable pacing systems suitable for patients with bradyarrhythmias or other contraindications to dual-chamber pacemakers.
    • RDPs effectively increase cardiac output by enabling heart rate increases during exercise, outperforming VVI pacing.
    • This technology provides a viable solution for enhancing cardiovascular performance in specific patient populations.