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Culture of Bladder Cancer Organoids as Precision Medicine Tools

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Published on: December 28, 2021

Reconstructing Phylogenetic Relationship in Bladder Cancer: A Methodological Overview.

Lancelot Seillier¹, Martin Peifer²

¹University Hospital RWTH Aachen University, Aachen, Germany. lseillier@ukaachen.de.

Methods in Molecular Biology (Clifton, N.J.)

|July 6, 2023

Summary

Bladder cancer is a complex disease with significant variations. This review explores tools for understanding its evolutionary history and spread, aiding in better treatment strategies.

Keywords:

Cancer cell fraction Clonal evolution Copy number analysis Data processing Genomics Phylogenetics Variant allele frequency

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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

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Area of Science:

Oncology
Genetics
Evolutionary Biology

Background:

Bladder cancer (BC) is characterized by significant histological and molecular heterogeneity.
Multifocal disease, recurrence, and metastasis are common challenges in bladder cancer management.
Existing sequencing studies highlight inter- and intrapatient heterogeneity, yet clonal evolution remains incompletely understood.

Approach:

This review provides an overview of technical and theoretical concepts for reconstructing evolutionary trajectories in bladder cancer.
It proposes a set of established software tools for conducting phylogenetic analysis.

Key Points:

Understanding clonal evolution is crucial for deciphering bladder cancer's complex behavior.
Phylogenetic analysis offers a framework for mapping the evolutionary history of bladder cancer.
Various computational tools are available to support these analyses.

Conclusions:

Reconstructing bladder cancer's evolutionary paths can illuminate mechanisms of recurrence and metastasis.
Phylogenetic tools can enhance our understanding of bladder cancer heterogeneity.
Further research into evolutionary trajectories may lead to improved therapeutic strategies for bladder cancer.