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Updated: Jul 24, 2025
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Impaired lung function in multiple sclerosis: a single-center observational study in 371 persons
Iván Murrieta-Álvarez1,2,3, José A Fernández-Gutiérrez1,2, Carlos A Pérez3
1Clínica Ruiz, Centro de Hematología y Medicina Interna, Puebla, México.
Summary
Pulmonary function abnormalities in multiple sclerosis (MS) worsen with disease progression. Central nervous system lesions, particularly in the corpus callosum, are linked to reduced lung function in MS patients.
Area of Science:
- Neurology
- Pulmonology
- Radiology
Background:
- Abnormal lung function in people with multiple sclerosis (PwMS) may stem from muscle weakness or central nervous system (CNS) abnormalities.
- These CNS abnormalities can exacerbate motor and cognitive symptoms in MS.
Purpose of the Study:
- To investigate the relationship between pulmonary function and CNS abnormalities in PwMS.
- To explore the association between specific brain lesions and lung function deficits.
Main Methods:
- A cross-sectional observational study involving 371 PwMS.
- Forced spirometry was used to assess lung function (FVC, FEV1, FEV1/FVC).
- Brain MRI (qualitative and quantitative) was performed to evaluate CNS structural changes.
Main Results:
- 16-25% of PwMS exhibited low FVC and FEV1, with higher prevalence in progressive MS subtypes.
- Corpus callosum T2-FLAIR lesions significantly correlated with reduced FVC and FEV1 (OR 3.62, p=0.012), especially in RRMS (OR 10.1, p=0.031).
- Increased FVC z-score was associated with larger hippocampal volumes (0.25 cm³ for overall hippocampus, 0.43 cm³ for left hippocampus).
Conclusions:
- Abnormal pulmonary function tests increase progressively with worsening MS disease courses (RRMS to PPMS/SPMS).
- CNS lesions, particularly in the corpus callosum, are associated with impaired lung function in PwMS.
- A positive correlation exists between lung function (FVC) and hippocampal volume in MS.
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