[Changes in the femur of fur-bearing animals during hypodynamia]

Under conditions of hypodynamia the form and internal architectonics of the femoral bone undergo certain changes. In young animals these changes are of quantitative character without any signs of a manifested destruction. Later on, certain indications of focal resorption appear in the spongy substance, as does partial destruction of the beams. Gradually, definite signs of osteoporosis and osteosclerosis as a result of dystrophic alterations in the osseous tissue develop. These phenomena, though progress with age, nevertheless, develop against the background of noticeable compensatory shifts in the osseous structures: increment in the mass of some osseous beams, appearance of new strengthening osseous plates in the spongiosa. The symptom complex at adaptational rearrangement of the bone under hypodynamia should be taken into account at differential diagnosis of these conditions both in the clinic and at experimental modelling.