Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aqueous vs viscous phenylephrine. II. Mydriatic effects.

J C Folk, V Kumar, J G Piper

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |August 1, 1986
    PubMed
    Summary

    There is no significant difference in the pupil dilation effect between aqueous and viscous 2.5% phenylephrine hydrochloride solutions. Both formulations showed similar mydriatic outcomes when used alone or with other ophthalmic agents.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multifocal electroretinography in multifocal choroiditis and the multiple evanescent white dot syndrome.

    Retina (Philadelphia, Pa.)·2002
    Same author

    Traumatic macular hole: observations, pathogenesis, and results of vitrectomy surgery.

    Ophthalmology·2001
    Same author

    In vitro and ex vivo hydrolysis rates of ethacrynate esters and their relationship to intraocular pressure in the rabbit eye.

    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics·2001
    Same author

    The ocular pharmacokinetics of ketanserin and its metabolite, ketanserinol, in albino rabbits.

    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics·2000
    Same author

    Evaluation of patients with visual field defects following macular hole surgery using multifocal electroretinography.

    Retina (Philadelphia, Pa.)·2000
    Same author

    Uptake of ibuprofen, indomethacin and ketoprofen into isolated rabbit parietal cells.

    The Journal of pharmacy and pharmacology·2000

    Area of Science:

    • Ophthalmology
    • Pharmacology

    Background:

    • Phenylephrine hydrochloride is commonly used to induce mydriasis.
    • The formulation (aqueous vs. viscous) may influence its efficacy.

    Purpose of the Study:

    • To compare the mydriatic effect of 2.5% aqueous versus 2.5% viscous phenylephrine hydrochloride solutions.
    • To evaluate the impact of pretreatment with anesthetic and combination therapy on mydriasis.

    Main Methods:

    • Four studies were conducted comparing aqueous and viscous phenylephrine.
    • Mydriasis was measured under room light and darkened conditions.
    • Studies included pretreatment with proparacaine hydrochloride and combination with tropicamide.

    Main Results:

    • No significant difference in mydriasis was observed between aqueous and viscous phenylephrine formulations.

    Related Experiment Videos

  • Pretreatment with proparacaine hydrochloride approximately doubled the dilation.
  • Combination with tropicamide resulted in a mean dilation of 3.8 mm for both formulations.

    • Conclusions:

    • The formulation (aqueous vs. viscous) of 2.5% phenylephrine hydrochloride does not affect its mydriatic efficacy.
    • Phenylephrine's mydriatic effect is enhanced by anesthetic pretreatment and combination with tropicamide.