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Updated: Jul 24, 2025

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Optical glucose sensor for microfluidic cell culture systems.

Stefanie Fuchs¹, Veronika Rieger¹, Anders Ø Tjell¹

¹Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9/II, 8010, Graz, Austria.

Biosensors & Bioelectronics

|July 6, 2023

Summary

This summary is machine-generated.

Researchers developed a miniaturized optical glucose sensor for microphysiological systems (MPS). This plug-and-play sensor enables stable glucose monitoring in cell cultures, addressing a key challenge in microfluidic systems.

Keywords:

Flow through cell Glucose Microfluidic Microphysiological systems Optical sensor Organ-on-Chip

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Area of Science:

Biomedical Engineering
Sensor Technology
Cell Culture Technology

Background:

Glucose is vital for human cell energy, making its monitoring crucial for assessing cell viability and metabolic status in microphysiological systems (MPS).
Current continuous glucose monitoring in MPS is hindered by the absence of appropriate miniaturized sensor solutions.

Purpose of the Study:

To develop and characterize a miniaturized, enzymatic, optical glucose sensor for integration into microfluidic systems.
To create a plug-and-play sensor system for easy integration with existing MPS and reliable glucose measurement under cell culture conditions.

Main Methods:

Fabrication of a 1 mm diameter enzymatic, optical glucose sensor element integrated with an oxygen sensor on biocompatible adhesive tape.
Characterization of the sensor's performance under cell culture conditions (37°C, pH 7.4) for five days, assessing drift and influence of parameters like oxygen, pH, flow rate, and sterilization.
Validation of the sensor system through at-line glucose measurements in static cell culture, comparing results with a commercial glucose sensor.

Main Results:

The developed sensor demonstrated stable performance with minor drift (3% day⁻¹) over five days under physiological cell culture conditions.
The sensor system showed good agreement with a commercial glucose sensor when used for at-line glucose measurements in static cell culture.
The influence of various cell culture parameters on sensor performance was investigated and documented.

Conclusions:

An easily integrable, miniaturized optical glucose sensor element for microfluidic systems has been successfully developed.
The developed sensor enables stable and reliable glucose measurements under cell culture conditions, addressing a critical need in MPS research.
The plug-and-play nature of the sensor system facilitates its application with existing MPS setups.