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Functional changes in neuronal circuits due to antibody-driven autoimmune response.

Timo Kirschstein1, Rüdiger Köhling1

  • 1Oscar-Langendorff-Institute of Physiology, Rostock University Medical Center, Gertrudenstraße 9, 18057 Rostock, Germany; Center for Translational Neuroscience Research, Rostock University Medical Center, 18057 Rostock, Germany.

Neurobiology of Disease
|July 6, 2023
PubMed
Summary

Autoimmune encephalitis requires prompt diagnosis for patients with rapid psychiatric and cognitive changes. Autoantibodies targeting neural surface antigens can cause brain dysfunction, highlighting the need for rapid diagnostic approaches.

Keywords:
Autoimmune encephalitisCASPR2ElectrophysiologyExcitabilityGAD65Kv1.2LGI1Limbic encephalitisNMDANetwork effectsSynaptic mechanismsSynaptic plasticity

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