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Growth differentiation factor 11: A new hope for the treatment of cardiovascular diseases

Yingchun Shao1, Yanhong Wang1, Jiazhen Xu1

  • 1The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao 266071, China.

Cytokine & Growth Factor Reviews
|July 6, 2023
PubMed

Insights

Growth Differentiation Factor 11 (GDF11) shows promise for treating cardiac aging and cardiovascular diseases (CVDs). This review details GDF11

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Molecular Signaling

Background:

  • Growth Differentiation Factor 11 (GDF11) is a key protein in the transforming growth factor-β superfamily.
  • GDF11 exhibits anti-cardiac aging properties and is implicated in cardiovascular disease (CVD) development.

Purpose of the Study:

  • To comprehensively review GDF11's structure, function, and signaling pathways.
  • To summarize current research on GDF11's role in CVD pathogenesis.
  • To explore GDF11's potential as a therapeutic target for CVDs.

Main Methods:

  • Literature review of studies on GDF11 and cardiovascular health.
  • Analysis of GDF11's molecular mechanisms and tissue-specific functions.
  • Evaluation of preclinical and clinical research on GDF11 for CVD treatment.

Main Results:

  • GDF11 plays a critical role in maintaining cardiac function and mitigating aging effects.
  • Dysregulation of GDF11 is linked to the progression of various cardiovascular diseases.
  • Emerging evidence supports GDF11's therapeutic potential in preclinical CVD models.

Conclusions:

  • GDF11 is a significant factor in cardiac aging and CVD development.
  • Further research into GDF11 signaling pathways is warranted for therapeutic development.
  • GDF11 holds promise as a novel therapeutic agent for cardiovascular conditions.
Keywords:
ApoptosisCardiovascular diseasesGDF11Growth differentiation factor 11Myocardial injury

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