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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
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Thrombospondin-1 in drug activity and tumor response to therapies

Elisa Longhi1, Laura Carminati1, Elena Carlessi1

  • 1Laboratory of Tumor Microenvironment, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Stezzano 87, Bergamo 24126, Italy.

Seminars in Cell & Developmental Biology
|July 6, 2023
PubMed

Insights

Thrombospondins (TSPs) regulate the tumor microenvironment and influence cancer therapy response. TSP-1 and TSP-2 show promise as biomarkers and therapeutic targets for enhancing anticancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Thrombospondins (TSPs) are multifunctional proteins crucial for cellular interactions within the tumor microenvironment (TME).
  • TSPs modulate cancer cell behavior, non-neoplastic cell functions, and tumor responses to environmental stimuli.
  • Their context-dependent interactions influence drug delivery, efficacy, and resistance in cancer therapy.

Purpose of the Study:

  • To review the multifaceted roles of TSPs, particularly TSP-1, in modulating tumor responses to various anticancer therapies.
  • To analyze the impact of TSPs on tumor cells, vascular endothelial cells, and immune cells within the TME.
  • To evaluate the potential of TSPs as prognostic and predictive biomarkers and as therapeutic targets.

Main Methods:

  • Literature review focusing on TSP-1 and its interactions within the TME.
  • Analysis of TSP activity across different cellular compartments (tumor, vascular, immune).
  • Examination of evidence for TSP roles in response to chemotherapy, antiangiogenic therapy, metronomic chemotherapy, immunotherapy, and radiotherapy.

Main Results:

  • TSPs significantly influence tumor response to diverse therapeutic modalities, with outcomes varying based on cellular context.
  • TSP-1 and TSP-2 are identified as valuable biomarkers for prognosis and predicting treatment response.
  • Understanding TSP interactions provides insights into therapeutic resistance mechanisms.

Conclusions:

  • TSPs play a critical, context-dependent role in cancer progression and response to therapy.
  • TSP-1 and TSP-2 hold significant potential as biomarkers for cancer prognosis and treatment efficacy.
  • Targeting TSPs offers a promising strategy for developing novel therapeutic approaches to enhance anticancer treatment outcomes.
Keywords:
Antiangiogenic low-dose metronomic chemotherapyBiomarkersChemotherapyImmunotherapyTSP-1Tumor microenvironment

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