A comprehensive review on human disease-causing bacterial proteases and their impeding agents
Shobana Sundar1, Shanmughavel Piramanayagam2, Jeyakumar Natarajan3
1Department of Biotechnology, PSG College of Technology, Coimbatore, India.
Archives of Microbiology
|July 6, 2023
Summary
Bacterial proteases contribute to human diseases by degrading host defenses and aiding pathogen virulence. This review explores cysteine, metallo, and serine bacterial proteases as potential drug targets and their inhibitors.
Area of Science:
- Biochemistry
- Microbiology
- Pharmacology
Background:
- Proteases are enzymes catalyzing peptide bond hydrolysis, crucial in biological processes.
- Bacterial proteases significantly impact human diseases, including cancers and infections.
- Extracellular proteases degrade host defenses, while intracellular proteases enhance pathogen virulence.
Purpose of the Study:
- To comprehensively review human disease-causing bacterial proteases.
- To identify and discuss potential inhibitors for these bacterial proteases.
- To highlight bacterial proteases as viable drug targets.
Main Methods:
- Literature review of scientific studies on bacterial proteases.
- Categorization of proteases into families (cysteine, metallo, serine).
- Analysis of protease roles in pathogenesis and virulence.
Main Results:
- Bacterial proteases are implicated in a wide range of human ailments.
- Extracellular and intracellular bacterial proteases play distinct roles in disease.
- Numerous potential inhibitors have been identified for various bacterial proteases.
Conclusions:
- Bacterial proteases are critical virulence factors and drug targets.
- Targeting bacterial proteases offers a promising therapeutic strategy.
- Further research into bacterial protease inhibitors is warranted.
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