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Updated: Jul 24, 2025
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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
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[Invasive meningococcal disease: increased risk and vaccination prevention for immunocompromised patients]
Sabrina Janßen1, Benjamin T Schleenvoigt2, Birgit Blass3
1Pfizer Pharma GmbH, Linkstraße 10, 10785, Berlin, Germany. Sabrina.Janssen2@pfizer.com.
MMW Fortschritte Der Medizin
|July 6, 2023
Summary
Individuals with weakened immune systems are at higher risk for severe meningococcal infections. Consistent implementation of vaccination guidelines for these vulnerable groups is crucial for preventing severe outcomes and long-term sequelae.
Area of Science:
- Immunology
- Infectious Diseases
- Public Health
Context:
- Meningococcal infections, including sepsis and meningitis, remain significant health concerns despite declining case numbers.
- Identifying at-risk populations is essential for developing targeted vaccination strategies.
Purpose:
- To highlight the increased risk of severe meningococcal disease in immunocompromised individuals.
- To emphasize the importance of adhering to vaccination recommendations for vulnerable groups.
Summary:
- People with primary or secondary immunodeficiencies (e.g., asplenia, HIV, diabetes, transplant recipients, those on immunomodulatory therapy) face a heightened risk of infection and severe disease from meningococcal pathogens.
- Despite medical advancements, mortality rates remain high, and survivors often experience severe long-term complications.
Impact:
- Consistent application of vaccination guidelines for immunocompromised individuals is vital in Germany.
- Enhanced education for patients, contacts, and healthcare providers about available vaccinations can reduce invasive meningococcal infections.
Keywords:
MeningococciNeisseria meningitidisimmunosuppressionindicationinfectionriskunderlying diseasevaccination recommendationMore Related Videos
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