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Effect of dilazep on decrease in myocardial pH during ischemia in dogs.

N Haga, I Miura, Y Fujisawa

    Arzneimittel-Forschung
    |June 1, 1986
    PubMed
    Summary
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    Dilazep significantly attenuates myocardial acidosis during ischemia in dogs by improving coronary artery blood flow. However, it did not restore ST segment elevation or contractile force.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Myocardial acidosis is a significant complication of myocardial ischemia.
    • Understanding interventions that can mitigate acidosis is crucial for cardiac protection.

    Purpose of the Study:

    • To investigate the effect of dilazep on myocardial acidosis induced by coronary artery occlusion in a canine model.
    • To assess dilazep's impact on myocardial blood flow, pH, and contractile function during ischemia.

    Main Methods:

    • Dogs underwent partial occlusion of the left anterior descending coronary artery to induce ischemia.
    • Dilazep was administered intravenously after the onset of ischemia.
    • Measurements included myocardial pH, ST segment changes, contractile force, and coronary artery blood flow.

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    Main Results:

    • Dilazep (500 micrograms/kg) significantly attenuated the decrease in myocardial pH during ischemia.
    • Dilazep administration led to a significant restoration of myocardial [H+] compared to saline.
    • Dilazep did not significantly improve ST segment elevation or restore myocardial contractile force.

    Conclusions:

    • Dilazep demonstrates a protective effect against myocardial acidosis during ischemic events.
    • The drug's beneficial effect on acidosis may be independent of its impact on ST elevation or contractile function.