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EEG functional connectivity after perinatal stroke.

Alja Kavčič1,2, Jure Demšar3,4, Dejan Georgiev3,5

  • 1Division of Pediatrics, Department of Neonatology, University Medical Centre Ljubljana, Bohoričeva 20, 1000 Ljubljana, Slovenia.

Cerebral Cortex (New York, N.Y. : 1991)
|July 6, 2023
PubMed
Summary
This summary is machine-generated.

Children with perinatal stroke show altered brain functional networks years later. These networks are more segregated and synchronized, with higher interhemispheric strength, influenced by lesion volume.

Keywords:
functional brain networksfunctional connectivityneonatal brain injuryperinatal strokeresting state EEG

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Background:

  • Perinatal stroke can lead to long-term cognitive impairments.
  • These impairments are linked to lasting changes in brain functional networks.
  • Understanding these network alterations is crucial for targeted interventions.

Purpose of the Study:

  • To investigate functional brain connectivity in children with a history of perinatal stroke.
  • To compare functional connectomes between children with perinatal stroke and healthy controls.
  • To explore the relationship between lesion volume and network changes.

Main Methods:

  • Utilized 64-channel resting-state electroencephalography (EEG) in 12 children (aged 5-14) with perinatal stroke and 16 age- and sex-matched healthy controls.
  • Calculated functional connectomes in the alpha frequency band for each participant.
  • Analyzed differences in network graph metrics between the stroke and control groups.

Main Results:

  • Children with perinatal stroke exhibited disrupted functional brain networks years post-insult.
  • Networks in the stroke group were more segregated and showed higher synchronization (whole-brain and intrahemispheric).
  • Total interhemispheric strength was significantly higher in children with perinatal stroke compared to controls, correlating with lesion volume.

Conclusions:

  • Perinatal stroke causes persistent disruptions in functional brain networks, detectable years after the initial event.
  • The degree of network alteration is influenced by the volume of the brain lesion.
  • These findings highlight the long-term impact of perinatal stroke on brain connectivity and network organization.