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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

998
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
998
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

517
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
517
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

710
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
710
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

2.5K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
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Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

743
Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...
743
Muscle Coordination and Action01:24

Muscle Coordination and Action

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Muscle coordination is a complex and finely tuned process essential for smooth and purposeful movements like flexion, extension, adduction, abduction, and rotation. The human body orchestrates the actions of various muscles working in concert, each with a specific role. Four functional types describe how muscles work together: agonist, antagonist, synergist, and fixator.
Agonists
Agonist muscles, often called prime movers, are the primary muscles responsible for producing a specific movement....
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Related Experiment Video

Updated: Jul 24, 2025

Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes
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Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes

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Cracking the code: unveiling the specific and shared mechanisms behind musculoskeletal interventions.

Amy W McDevitt1, Bryan O'Halloran2, Chad E Cook3,4,5

  • 1Department of Physical Medicine and Rehabilitation, University of Colorado, Anschutz Medical Campus, CO, Aurora, USA. amy.mcdevitt@cuanschutz.edu.

Archives of Physiotherapy
|July 6, 2023
PubMed
Summary

Understanding treatment mechanisms is crucial for enhancing efficacy. Research into how interventions work, particularly manual therapy, can optimize patient outcomes by tailoring treatments.

Keywords:
Manual therapy researchMechanisms of manual therapyPhysiotherapy

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Related Experiment Videos

Last Updated: Jul 24, 2025

Application of Consistent Massage-Like Perturbations on Mouse Calves and Monitoring the Resulting Intramuscular Pressure Changes
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Area of Science:

  • Clinical Research
  • Intervention Science

Background:

  • Mechanisms explain the processes by which interventions produce changes in outcomes.
  • Understanding "how" treatments work is vital for theory development and improving treatment efficacy.
  • Evaluating the mechanisms of action is as important as determining if a treatment works.

Purpose of the Study:

  • To highlight the importance of mechanisms research in understanding treatment effects.
  • To emphasize the potential of mechanisms research for optimizing patient outcomes.
  • To advocate for prioritizing mechanisms research in manual therapy.

Main Methods:

  • This study emphasizes the need for a unique research design to investigate mechanisms.
  • Focuses on the qualitative and quantitative evaluation of intervention processes.
  • Calls for studies that dissect the 'how' behind therapeutic effects.

Main Results:

  • Mechanisms research is currently in its early stages but shows significant promise.
  • Identifying specific and shared mechanisms can lead to personalized treatment approaches.
  • Prioritizing mechanisms research can yield valuable insights into treatment optimization.

Conclusions:

  • Mechanisms research is an underexplored but critical area for advancing therapeutic interventions.
  • Tailoring treatments based on specific patient needs and intervention mechanisms can improve outcomes.
  • Further research into the mechanisms of manual therapy is essential for optimizing patient care.