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Open study of the clinical effect of suprofen drops in children

G Weippl, K Baerlocher, N Michos

    Arzneimittel-Forschung
    |June 1, 1986
    PubMed

    Insights

    Suprofen (alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid) effectively reduced fever in children. This antipyretic medication demonstrated good tolerability and acceptance in an open study.

    Area of Science:

    • Pediatrics
    • Pharmacology
    • Clinical Medicine

    Background:

    • Fever is a common symptom in children requiring effective and safe management.
    • Alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen) is a non-steroidal anti-inflammatory drug (NSAID) with potential antipyretic properties.

    Purpose of the Study:

    • To evaluate the antipyretic effect of suprofen drops in children with fever.
    • To assess the tolerability and acceptance of suprofen drops in a pediatric population.

    Main Methods:

    • An open-label study was conducted with 111 children experiencing fever of various etiologies.
    • Suprofen drops were administered based on body weight and age, up to four times daily for a maximum of four days.
    • Rectal temperature, pulse rate, and respiratory rate were monitored at multiple time points post-administration.

    Main Results:

    • An 89% good appreciation of the antipyretic effect was reported.
    • Statistically significant reductions in body temperature were observed at all measured time points after the first dose.
    • Adverse drug experiences (vomiting, loose stools) were infrequent (5 cases), with good tolerability (96%) and acceptance (94%) noted.

    Conclusions:

    • Suprofen drops demonstrated significant efficacy as an antipyretic agent in children.
    • The medication was well-tolerated and accepted by the pediatric patients in this study.
    • Suprofen represents a potentially valuable option for fever management in children.

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