Ingestible pH Sensing Capsule with Thread-Based Electrochemical Sensors.

Area of Science:

• Biomedical Engineering
• Gastroenterology
• Sensor Technology

Background:

• Current gastrointestinal disorder diagnostics (biopsy, endoscopy, colonoscopy) are invasive, costly, and time-consuming.
• These methods have limited reach, especially in the small intestine.
• pH is a crucial biomarker for various gastrointestinal conditions, including inflammatory bowel disease.

Purpose of the Study:

• To demonstrate a novel smart ingestible biosensing capsule for monitoring intestinal pH.
• To provide a less invasive and more accessible diagnostic alternative.

Main Methods:

• Integration of functionalized threads as pH sensing elements.
• Incorporation of front-end readout electronics.
• Utilization of a 3D-printed casing for capsule construction.
• Development of a modular sensing system design.

Main Results:

• Successful integration of pH sensing threads with electronics and casing.
• Demonstration of a functional ingestible biosensing capsule.
• A modular design that simplifies fabrication and assembly.

Conclusions:

• The developed ingestible biosensing capsule offers a promising approach for monitoring intestinal pH.
• This technology can potentially improve the diagnosis of gastrointestinal disorders.
• The modular design facilitates easier development and manufacturing of such devices.